Anti-AFAP1 antibody (STJA0007195)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human AFAP1
General Information
| Short Description | Rabbit polyclonal anti-Actin filament-associated protein 1 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AFAP1 |
| Gene ID | 60312 |
| Uniprot ID | AFAP1_HUMAN |
| Immunogen | Synthesized peptide derived from human AFAP1 |
| Specificity | This antibody detects endogenous levels of AFAP1 at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine residues by SRC. |
| Function | Can cross-link actin filaments into both network and bundle structures. May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. |
| Protein Name | Actin Filament-Associated Protein 1110 Kda Actin Filament-Associated ProteinAfap-110 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonStress Fiber |
| Alternative Antibody Names | Anti-Actin Filament-Associated Protein 1 antibodyAnti-110 Kda Actin Filament-Associated Protein antibodyAnti-Afap-110 antibodyAnti-AFAP1 antibodyAnti-AFAP antibody |
Information sourced from Uniprot.org