| Host: |
Rabbit |
| Applications: |
WB/IHC-P/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IHC-P:1:50-1:100IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ADRA1A |
| Gene ID: |
148 |
| Uniprot ID: |
ADA1A_HUMAN |
| Immunogen Region: |
346-475 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 346-475 of human ADRA1A (NP_150646.3). |
| Immunogen Sequence: |
LCRKQSSKHALGYTLHPPSQ AVEGQHKDMVRIPVGSRETF YRISKTDGVCEWKFFSSMPR GSARITVSKDQSSCTTARTK SRSVTRLECSGMILAHCNLR LPGSRDSPASASQAAGTTGM CHQADATRPS |
| Tissue Specificity | Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart. |
| Post Translational Modifications | C-terminal Ser or Thr residues may be phosphorylated. |
| Function | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. |
| Protein Name | Alpha-1a Adrenergic ReceptorAlpha-1a AdrenoreceptorAlpha-1a AdrenoceptorAlpha-1c Adrenergic ReceptorAlpha-Adrenergic Receptor 1c |
| Database Links | Reactome: R-HSA-390696Reactome: R-HSA-416476Reactome: R-HSA-416482 |
| Cellular Localisation | Nucleus MembraneMulti-Pass Membrane ProteinCell MembraneCytoplasmMembraneCaveolaLocation At The Nuclear Membrane Facilitates Heterooligomerization And Regulates Erk-Mediated Signaling In Cardiac MyocytesColocalizes With GnaqPlcb1 As Well As Lap2 At The Nuclear Membrane Of Cardiac Myocytes |
| Alternative Antibody Names | Anti-Alpha-1a Adrenergic Receptor antibodyAnti-Alpha-1a Adrenoreceptor antibodyAnti-Alpha-1a Adrenoceptor antibodyAnti-Alpha-1c Adrenergic Receptor antibodyAnti-Alpha-Adrenergic Receptor 1c antibodyAnti-ADRA1A antibodyAnti-ADRA1C antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
