Anti-ADPRS antibody (STJA0008686)

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STJA0008686
€58.80 - €313.20
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Short Description :Rabbit polyclonal anti-ADP-ribosylhydrolase ARH3 glycohydrolase ARH3 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents.
Applications:WB
Host:Rabbit
Reactivity:Human/Mouse
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Polyclonal
Isotype:IgG
Conjugation:Unconjugated
Concentration:1 mg/mL
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Dilution Range:WB 1:500-2000
Formulation:Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol:ADPRS
Gene ID:54936
Uniprot ID:ADPRS_HUMAN
Immunogen:Synthesized peptide derived from human ARH3
Specificity:This antibody detects endogenous levels of ARH3 at Human, Mouse
Function ADP-ribosylhydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine and threonine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose. Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds. Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos. Also hydrolyzes free poly(ADP-ribose) in mitochondria. Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins. Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers.
Protein Name Adp-Ribosylhydrolase Arh3
Adp-Ribose Glycohydrolase Arh3
Adp-Ribosylhydrolase 3
O-Acetyl-Adp-Ribose Deacetylase Arh3
Poly(Adp-Ribose Glycohydrolase Arh3
Protein Adp-Ribosylarginine Hydrolase-Like Protein 2
Protein Adp-Ribosylserine Hydrolase
Database Links Reactome: R-HSA-110362
Cellular Localisation Nucleus
Cytoplasm
Chromosome
Mitochondrion Matrix
Recruited To Dna Lesion Regions Following Dna Damage
Adp-D-Ribose-Recognition Is Required For Recruitment To Dna Damage Sites
Alternative Antibody Names Anti-Adp-Ribosylhydrolase Arh3 antibody
Anti-Adp-Ribose Glycohydrolase Arh3 antibody
Anti-Adp-Ribosylhydrolase 3 antibody
Anti-O-Acetyl-Adp-Ribose Deacetylase Arh3 antibody
Anti-Poly(Adp-Ribose Glycohydrolase Arh3 antibody
Anti-Protein Adp-Ribosylarginine Hydrolase-Like Protein 2 antibody
Anti-Protein Adp-Ribosylserine Hydrolase antibody
Anti-ADPRS antibody
Anti-ADPRHL2 antibody
Anti-ARH3 antibody

Information sourced from Uniprot.org

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