| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Adiponectin Receptor 1 (1-136) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ADIPOR1 |
| Gene ID: |
51094 |
| Uniprot ID: |
PAQR1_HUMAN |
| Immunogen Region: |
1-136 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-136 of human Adiponectin Receptor 1 (NP_057083.2). |
| Immunogen Sequence: |
MSSHKGSVVAQGNGAPASNR EADTVELAELGPLLEEKGKR VIANPPKAEEEQTCPVPQEE EEEVRVLTLPLQAHHAMEKM EEFVYKVWEGRWRVIPYDVL PDWLKDNDYLLHGHRPPMPS FRACFKSIFRIHTETG |
| Tissue Specificity | Widely expressed. Highly expressed in heart and skeletal muscle. Expressed at intermediate level in brain, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine. |
| Function | Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin. |
| Protein Name | Adiponectin Receptor Protein 1Progestin And Adipoq Receptor Family Member 1Progestin And Adipoq Receptor Family Member I |
| Database Links | Reactome: R-HSA-163680 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLocalized To The Cell Membrane And Intracellular Organelles |
| Alternative Antibody Names | Anti-Adiponectin Receptor Protein 1 antibodyAnti-Progestin And Adipoq Receptor Family Member 1 antibodyAnti-Progestin And Adipoq Receptor Family Member I antibodyAnti-ADIPOR1 antibodyAnti-PAQR1 antibodyAnti-TESBP1A antibodyAnti-CGI-45 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and SNAPIN knockout (KO) HeLa cells, using [KO Validated] SNAPIN Rabbit polyclonal antibody (STJ11100856) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89790/358261/STJ11100856_1__86855.1713122601.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and SNAPIN knockout (KO) HeLa cells, using [KO Validated] SNAPIN Rabbit polyclonal antibody (STJ11100856) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")
