| Function | Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation. |
| Protein Name | Alcohol Dehydrogenase Class-3Alcohol Dehydrogenase 5Alcohol Dehydrogenase Class Chi ChainAlcohol Dehydrogenase Class-IiiGlutathione-Dependent Formaldehyde DehydrogenaseFaldhFdhGsh-FdhS-(Hydroxymethylglutathione Dehydrogenase |
| Database Links | Reactome: R-HSA-71384 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Alcohol Dehydrogenase Class-3 antibodyAnti-Alcohol Dehydrogenase 5 antibodyAnti-Alcohol Dehydrogenase Class Chi Chain antibodyAnti-Alcohol Dehydrogenase Class-Iii antibodyAnti-Glutathione-Dependent Formaldehyde Dehydrogenase antibodyAnti-Faldh antibodyAnti-Fdh antibodyAnti-Gsh-Fdh antibodyAnti-S-(Hydroxymethylglutathione Dehydrogenase antibodyAnti-ADH5 antibodyAnti-ADHX antibodyAnti-FDH antibody |
Information sourced from Uniprot.org
