| Post Translational Modifications | Proteolytically cleaved into 2 conserved sites: one in the GPS region of the GAIN-B domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS region occurred independent of and probably prior to the cleavage at the S2 site. Proteolytic cleavage is required for activation of the receptor. Highly glycosylated. |
| Function | Adhesion G-protein coupled receptor (aGPCR) for steroid hormones, such as progesterone and 17alpha-hydroxyprogesterone (17OHP). Involved in many biological processes, such as myelination, sprouting angiogenesis, placenta, ear and cartilage development. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRG6 is coupled to G(i) G alpha proteins and mediates inhibition of adenylate cyclase. Also able to couple to G(q) G proteins. Involved in myelination of the peripheral nervous system: required for differentiation of promyelinating Schwann cells and for normal myelination of axons. Also acts as a regulator of body length and bone mass. Acts as a regulator of blood-brain barrier formation in the central nervous system vie its association with LRP1 and ITGB1. |
| Protein Name | Adhesion G-Protein Coupled Receptor G6Developmentally Regulated G-Protein-Coupled ReceptorG-Protein Coupled Receptor 126Vascular Inducible G Protein-Coupled Receptor Cleaved Into - Adhesion G-Protein Coupled Receptor G6 - N-Terminal FragmentAdgrg6 N-Terminal FragmentAdgrg6-Ntf - Adhesion G-Protein Coupled Receptor G6 - C-Terminal FragmentAdgrg6 C-Terminal FragmentAdgrg6-Ctf |
| Database Links | Reactome: R-HSA-9619665 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinDetected On The Cell Surface Of Activated But Not Resting Umbilical Vein |
| Alternative Antibody Names | Anti-Adhesion G-Protein Coupled Receptor G6 antibodyAnti-Developmentally Regulated G-Protein-Coupled Receptor antibodyAnti-G-Protein Coupled Receptor 126 antibodyAnti-Vascular Inducible G Protein-Coupled Receptor Cleaved Into - Adhesion G-Protein Coupled Receptor G6 - N-Terminal Fragment antibodyAnti-Adgrg6 N-Terminal Fragment antibodyAnti-Adgrg6-Ntf - Adhesion G-Protein Coupled Receptor G6 - C-Terminal Fragment antibodyAnti-Adgrg6 C-Terminal Fragment antibodyAnti-Adgrg6-Ctf antibodyAnti-ADGRG6 antibodyAnti-DREG antibodyAnti-GPR126 antibodyAnti-VIGR antibody |
Information sourced from Uniprot.org
