| Post Translational Modifications | Autoproteolytically processed at the GPS region of the GAIN-B domain.this cleavage modulates receptor activity. Glycosylated. Glycosylation at Asn-389 is required for secretion or folding. |
| Function | Adhesion G-protein coupled receptor (aGPCR) for N-docosahexaenoylethanolamine (synaptamide), an omega-3 fatty acid lipid highly enriched in the brain. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRF1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Also able to couple to G(q), G(i) and G(12)/G(13) G proteins.additional evidence is however required to confirm this result in vivo. Involved in the development of neurons and cognitive function. In liver, involved in fat accumulation. |
| Protein Name | Adhesion G-Protein Coupled Receptor F1G Protein-Coupled Receptor 110G Protein-Coupled Receptor Kpg_012 Cleaved Into - Adhesion G-Protein Coupled Receptor F1 - N-Terminal FragmentAdgrf1 N-Terminal Fragment - Adhesion G-Protein Coupled Receptor F1 - C-Terminal FragmentAdgrf1 C-Terminal Fragment |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinIsoform 2: Secreted |
| Alternative Antibody Names | Anti-Adhesion G-Protein Coupled Receptor F1 antibodyAnti-G Protein-Coupled Receptor 110 antibodyAnti-G Protein-Coupled Receptor Kpg_012 Cleaved Into - Adhesion G-Protein Coupled Receptor F1 - N-Terminal Fragment antibodyAnti-Adgrf1 N-Terminal Fragment - Adhesion G-Protein Coupled Receptor F1 - C-Terminal Fragment antibodyAnti-Adgrf1 C-Terminal Fragment antibodyAnti-ADGRF1 antibodyAnti-GPR110 antibodyAnti-PGR19 antibody |
Information sourced from Uniprot.org
