Anti-ADGRF1 antibody (831-880 aa) (STJ93320)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human GPR110 at the amino acid range 831-880
General Information
| Short Description | Rabbit polyclonal anti-Adhesion G-protein coupled receptor F1 (831-880 aa) for use in WB, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IF 1:200-1:1000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ADGRF1 |
| Gene ID | 266977 |
| Uniprot ID | AGRF1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human GPR110 at the amino acid range 831-880 |
| Immunogen Region | 831-880 aa |
| Specificity | GPR110 Polyclonal Antibody detects endogenous levels of GPR110 protein. |
Additional Info
| Post Translational Modifications | Autoproteolytically processed at the GPS region of the GAIN-B domain.this cleavage modulates receptor activity. Glycosylated. Glycosylation at Asn-389 is required for secretion or folding. |
| Function | Adhesion G-protein coupled receptor (aGPCR) for N-docosahexaenoylethanolamine (synaptamide), an omega-3 fatty acid lipid highly enriched in the brain. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRF1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Also able to couple to G(q), G(i) and G(12)/G(13) G proteins.additional evidence is however required to confirm this result in vivo. Involved in the development of neurons and cognitive function. In liver, involved in fat accumulation. |
| Protein Name | Adhesion G-Protein Coupled Receptor F1G Protein-Coupled Receptor 110G Protein-Coupled Receptor Kpg_012 Cleaved Into - Adhesion G-Protein Coupled Receptor F1 - N-Terminal FragmentAdgrf1 N-Terminal Fragment - Adhesion G-Protein Coupled Receptor F1 - C-Terminal FragmentAdgrf1 C-Terminal Fragment |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinIsoform 2: Secreted |
| Alternative Antibody Names | Anti-Adhesion G-Protein Coupled Receptor F1 antibodyAnti-G Protein-Coupled Receptor 110 antibodyAnti-G Protein-Coupled Receptor Kpg_012 Cleaved Into - Adhesion G-Protein Coupled Receptor F1 - N-Terminal Fragment antibodyAnti-Adgrf1 N-Terminal Fragment - Adhesion G-Protein Coupled Receptor F1 - C-Terminal Fragment antibodyAnti-Adgrf1 C-Terminal Fragment antibodyAnti-ADGRF1 antibodyAnti-GPR110 antibodyAnti-PGR19 antibody |
Information sourced from Uniprot.org