| Host: | Rabbit |
| Applications: | WB/IF/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Adhesion G protein-coupled receptor E2 (765-814 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IF 1:200-1:1000 ELISA 1:20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ADGRE2 |
| Gene ID: | 30817 |
| Uniprot ID: | AGRE2_HUMAN |
| Immunogen Region: | 765-814 aa |
| Specificity: | EMR2 Polyclonal Antibody detects endogenous levels of EMR2 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human EMR2 at the amino acid range 765-814 |
| Post Translational Modifications | Autoproteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane beta subunit. |
| Function | Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation. |
| Protein Name | Adhesion G Protein-Coupled Receptor E2 Egf-Like Module Receptor 2 Egf-Like Module-Containing Mucin-Like Hormone Receptor-Like 2 Cd Antigen Cd312 |
| Database Links | Reactome: R-HSA-373080 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Cell Projection Ruffle Membrane Localized At The Leading Edge Of Migrating Cells |
| Alternative Antibody Names | Anti-Adhesion G Protein-Coupled Receptor E2 antibody Anti-Egf-Like Module Receptor 2 antibody Anti-Egf-Like Module-Containing Mucin-Like Hormone Receptor-Like 2 antibody Anti-Cd Antigen Cd312 antibody Anti-ADGRE2 antibody Anti-EMR2 antibody |
Information sourced from Uniprot.org