| Post Translational Modifications | Autoproteolytically processed at the GPS region of the GAIN-B domain.this cleavage modulates receptor activity . Cleavage takes place early in the secretory pathway before N-glycosylation. |
| Function | Adhesion G-protein coupled receptor (aGPCR) for androgen hormone 5alpha-dihydrotestosterone (5alpha-DHT), also named 17beta-hydroxy-5alpha-androstan-3-one, the most potent hormone among androgens. Also activated by methenolone drug. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRD1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Acts as a 5alpha-DHT receptor in muscle cells, thereby increasing intracellular cyclic AMP (cAMP) levels and enhancing muscle strength. |
| Protein Name | Adhesion G-Protein Coupled Receptor D1G-Protein Coupled Receptor 133G-Protein Coupled Receptor Pgr25 Cleaved Into - Adhesion G-Protein Coupled Receptor D1 - N-Terminal FragmentAdgrd1 N-Terminal Fragment - Adhesion G-Protein Coupled Receptor D1 - C-Terminal FragmentAdgrd1 C-Terminal Fragment |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Adhesion G-Protein Coupled Receptor D1 antibodyAnti-G-Protein Coupled Receptor 133 antibodyAnti-G-Protein Coupled Receptor Pgr25 Cleaved Into - Adhesion G-Protein Coupled Receptor D1 - N-Terminal Fragment antibodyAnti-Adgrd1 N-Terminal Fragment - Adhesion G-Protein Coupled Receptor D1 - C-Terminal Fragment antibodyAnti-Adgrd1 C-Terminal Fragment antibodyAnti-ADGRD1 antibodyAnti-GPR133 antibodyAnti-PGR25 antibody |
Information sourced from Uniprot.org
