| Short Description : | Rabbit polyclonal ADGRB3 (70-280) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ADGRB3 |
| Gene ID: | 577 |
| Uniprot ID: | AGRB3_HUMAN |
| Immunogen Region: | 70-280 |
| Immunogen Sequence: | YLKFSKKDLSCSNFSLLAYQ FDHFSHEKIKDLLRKNHSIM QLCNSKNAFVFLQYDKNFIQ IRRVFPTNFPGLQKKGEEDQ KSFFEFLVLNKVSPSQFGCH VLCTWLESCLKSENGRTESC GIMYTKCTCPQHLGEWGIDD QSLILLNNVVLPLNEQTEGC LTQELQTTQVCNLTREAKRP PKEEFGMMGDHTIKSQRPRS VHEKRVPQEQA |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 70-280 of human ADGRB3 (NP_001695.1). |
| Tissue Specificity | Strongly expressed in brain. Also detected in heart. Reduced expression in some glioblastoma cell lines. |
| Post Translational Modifications | The endogenous protein is proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. |
| Function | Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity. Promotes myoblast fusion through ELMO/DOCK1. |
| Protein Name | Adhesion G Protein-Coupled Receptor B3Brain-Specific Angiogenesis Inhibitor 3 |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Adhesion G Protein-Coupled Receptor B3 antibodyAnti-Brain-Specific Angiogenesis Inhibitor 3 antibodyAnti-ADGRB3 antibodyAnti-BAI3 antibodyAnti-KIAA0550 antibody |
Information sourced from Uniprot.org
