| Host: | Rabbit |
| Applications: | ELISA/WB |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Adenylate cyclase 1 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Biotin |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.72 µg/µl |
| Dilution Range: | WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | Adcy1 |
| Gene ID: | 432530 |
| Uniprot ID: | ADCY1_MOUSE |
| Immunogen Region: | C-Term |
| Immunogen: | Synthetic peptide corresponding to conserved sequence at or near C terminal end of protein that is unique to rat/mouse Adenylyl Cyclase 1 protein. |
| Tissue Specificity | Expressed throughout inner ear development. |
| Post Translational Modifications | N-glycosylated. |
| Function | Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels. May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina. |
| Protein Name | Adenylate Cyclase Type 1 Atp Pyrophosphate-Lyase 1 Adenylate Cyclase Type I Adenylyl Cyclase 1 Ca(2+/Calmodulin-Activated Adenylyl Cyclase |
| Database Links | Reactome: R-MMU-163615 Reactome: -MMU-170660 Reactome: -MMU-170670 Reactome: -MMU-418597 Reactome: -MMU-5610787 |
| Cellular Localisation | Membrane Multi-Pass Membrane Protein Cell Membrane Cytoplasm Membrane Raft Expressed In The Cytoplasm Of Supporting Cells And Hair Cells Of The Cochlea Vestibule As Well As To The Cochlear Hair Cell Nuclei And Stereocilia| |
| Alternative Antibody Names | Anti-Adenylate Cyclase Type 1 antibody Anti-Atp Pyrophosphate-Lyase 1 antibody Anti-Adenylate Cyclase Type I antibody Anti-Adenylyl Cyclase 1 antibody Anti-Ca(2+/Calmodulin-Activated Adenylyl Cyclase antibody Anti-Adcy1 antibody |
Information sourced from Uniprot.org