| Tissue Specificity | Expressed in brain.protein levels are markedly increased in brain from subjects with Parkinson disease and subjects with dementia with Lewy bodies. Detected in pyramidal neurons located throughout the cingulate cortex (at protein level). In the substantia nigra, it is found in neuromelanin-positive dopaminergic neurons (at protein level). |
| Post Translational Modifications | Autophosphorylated. Accumulates in an inactive autophosphorylated state and autophosphorylation is stimulated by phosphatidic acid and phosphatidylinositol 3,5-bisphosphate but not by Mn(2+) or Zn(2+). The presence of spermine results in a dose-dependent reduction in autophosphorylation. |
| Function | ATPase which acts as a lysosomal polyamine exporter with high affinity for spermine. Also stimulates cellular uptake of polyamines and protects against polyamine toxicity. Plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Contributes to cellular zinc homeostasis. Confers cellular protection against Mn(2+) and Zn(2+) toxicity and mitochondrial stress. Required for proper lysosomal and mitochondrial maintenance. Regulates the autophagy-lysosome pathway through the control of SYT11 expression at both transcriptional and post-translational levels. Facilitates recruitment of deacetylase HDAC6 to lysosomes to deacetylate CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy. Promotes secretion of exosomes as well as secretion of SCNA via exosomes. Plays a role in lipid homeostasis. |
| Protein Name | Polyamine-Transporting Atpase 13a2 |
| Database Links | Reactome: R-HSA-936837 |
| Cellular Localisation | Lysosome MembraneMulti-Pass Membrane ProteinLate Endosome MembraneEndosomeMultivesicular Body MembraneCytoplasmic VesicleAutophagosome Membrane |
| Alternative Antibody Names | Anti-Polyamine-Transporting Atpase 13a2 antibodyAnti-ATP13A2 antibodyAnti-PARK9 antibody |
Information sourced from Uniprot.org
