| Tissue Specificity | Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta. |
| Function | G protein-coupled receptor activated by the neuropeptide pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds both PACAP27 and PACAP38 bioactive peptides. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract. |
| Protein Name | Pituitary Adenylate Cyclase-Activating Polypeptide Type I ReceptorPac1 ReceptorPac1rPacap Type I ReceptorPacap-R-1Pacap-R1 |
| Database Links | Reactome: R-HSA-187024Reactome: R-HSA-418555Reactome: R-HSA-420092 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Pituitary Adenylate Cyclase-Activating Polypeptide Type I Receptor antibodyAnti-Pac1 Receptor antibodyAnti-Pac1r antibodyAnti-Pacap Type I Receptor antibodyAnti-Pacap-R-1 antibodyAnti-Pacap-R1 antibodyAnti-ADCYAP1R1 antibody |
Information sourced from Uniprot.org
