| Host: | Rabbit |
| Applications: | ELISA/IHC/IP/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-ADCYAP1 (125-176) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.5-1.5 µg/µl |
| Dilution Range: | WB: 1:2, 500-1:5, 000 ELISA: 1:50, 000 IP: 1:200 IHC: 1:50-1:250 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | ADCYAP1 |
| Gene ID: | 116 |
| Uniprot ID: | PACA_HUMAN |
| Immunogen Region: | 125-176 |
| Immunogen: | Synthetic peptide taken within amino acid region 125-176 on human Pituitary adenylate cyclase-activating polypeptide protein. |
| Function | Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion. Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells. |
| Protein Name | Pituitary Adenylate Cyclase-Activating Polypeptide Pacap Cleaved Into - Pacap-Related Peptide Prp-48 - Pituitary Adenylate Cyclase-Activating Polypeptide 27 Pacap-27 Pacap27 - Pituitary Adenylate Cyclase-Activating Polypeptide 38 Pacap-38 Pacap38 |
| Database Links | Reactome: R-HSA-187024 Reactome: R-HSA-418555 Reactome: R-HSA-420092 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Pituitary Adenylate Cyclase-Activating Polypeptide antibody Anti-Pacap Cleaved Into - Pacap-Related Peptide antibody Anti-Prp-48 - Pituitary Adenylate Cyclase-Activating Polypeptide 27 antibody Anti-Pacap-27 antibody Anti-Pacap27 - Pituitary Adenylate Cyclase-Activating Polypeptide 38 antibody Anti-Pacap-38 antibody Anti-Pacap38 antibody Anti-ADCYAP1 antibody |
Information sourced from Uniprot.org