| Host: | Rabbit |
| Applications: | IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Adenylate cyclase type 8/calmodulin-activated adenylyl cyclase (591-640 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC 1:100-1:300IF 1:200-1:1000ELISA 1:40000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ADCY8 |
| Gene ID: | 114 |
| Uniprot ID: | ADCY8_HUMAN |
| Immunogen Region: | 591-640 aa |
| Specificity: | A Cyclase VIII Polyclonal Antibody detects endogenous levels of A Cyclase VIII protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human ADCY8 at the amino acid range 591-640 |
| Post Translational Modifications | Phosphorylated by PKA.mediates inhibition of adenylate cyclase activity at membrane raft.does not influence either CALM1 or PPP2CA interaction with ADCY8. N-glycosylated.N-glycosylation is responsible for raft-targeting.is not necessary for CCE-stimulated adenylate cyclase activity. |
| Function | Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells. |
| Protein Name | Adenylate Cyclase Type 8Atp Pyrophosphate-Lyase 8Adenylate Cyclase Type ViiiAdenylyl Cyclase 8Ac8Ca(2+/Calmodulin-Activated Adenylyl Cyclase |
| Database Links | Reactome: R-HSA-163359Reactome: R-HSA-163615Reactome: R-HSA-164378Reactome: R-HSA-170660Reactome: R-HSA-170670Reactome: R-HSA-381676Reactome: R-HSA-418555Reactome: R-HSA-418594Reactome: R-HSA-418597Reactome: R-HSA-432040Reactome: R-HSA-442720Reactome: R-HSA-5610787Reactome: R-HSA-9634597Reactome: R-HSA-9660821Reactome: R-HSA-9664323 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneApical Cell MembraneSynapseCell ProjectionDendriteAxonPresynaptic Cell MembranePostsynaptic DensityMembrane RaftMembraneCoated PitCytoplasmic VesicleClathrin-Coated Vesicle MembraneCaveolaLocalized To Dendritic ArborsMonomeric N-Glycosylated Species Localizes In Membrane RaftIn ContrastMonomeric Unglycosylated Forms Are Enriched In Clathrin-Coated Pits And VesiclesDimers Are Also Localized Outside Of Membrane RaftsMembrane Raft Localization And Integrity Is Indispensable For Cce-Stimulated Adenylate Cyclase Activity |
| Alternative Antibody Names | Anti-Adenylate Cyclase Type 8 antibodyAnti-Atp Pyrophosphate-Lyase 8 antibodyAnti-Adenylate Cyclase Type Viii antibodyAnti-Adenylyl Cyclase 8 antibodyAnti-Ac8 antibodyAnti-Ca(2+/Calmodulin-Activated Adenylyl Cyclase antibodyAnti-ADCY8 antibody |
Information sourced from Uniprot.org
