| Host: |
Rabbit |
| Applications: |
CM/ELISA/ICC/IF/IHC/IP/WB |
| Reactivity: |
Bovine/Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ADCY7 is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Biotin |
| Isotype: |
IgG |
| Purification: |
Affinity Purified |
| Concentration: |
0.75 µg/µl |
| Dilution Range: |
WB: 1:500DB: 1:10, 000ELISA: 1:10, 000IP: 1:200IHC: 1:100-1:200ICC: 1:100-1:200IF: 1:100-1:200CFM: 1:100-1:200 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Adcy7 |
| Gene ID: |
11513 |
| Uniprot ID: |
ADCY7_MOUSE |
| Specificity: |
Does not cross react with other Adenylate cyclases. |
| Immunogen: |
Synthetic peptide corresponding to unique amino acid sequence on mouse Particulate Adenylyl Cyclase 7 protein. |
| Tissue Specificity | Most abundant in heart, spleen and lung. |
| Post Translational Modifications | Phosphorylated by PRKCD. |
| Function | Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13. Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex. Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells. |
| Protein Name | Adenylate Cyclase Type 7Atp Pyrophosphate-Lyase 7Adenylate Cyclase Type ViiAdenylyl Cyclase 7 |
| Database Links | Reactome: R-MMU-163615Reactome: -MMU-170660Reactome: -MMU-170670Reactome: -MMU-418597Reactome: -MMU-5610787 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Adenylate Cyclase Type 7 antibodyAnti-Atp Pyrophosphate-Lyase 7 antibodyAnti-Adenylate Cyclase Type Vii antibodyAnti-Adenylyl Cyclase 7 antibodyAnti-Adcy7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
