Anti-ADCY3 antibody (STJ502055)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide generated against a sequence unique to PAC3 protein. All peptides were amidated before conjugation.
General Information
| Short Description | Rabbit polyclonal antibody anti-ADCY3 is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Applications | ELISA/IHC/IP/WB |
| Host | Rabbit |
| Reactivity | Dog/Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.68 ยตg/ยตl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500DB: 1:10, 000ELISA: 1:10, 000IP: 1:200IHC: 1:50-1:150 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20ยฐC for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | ADCY3 |
| Gene ID | 109 |
| Uniprot ID | ADCY3_HUMAN |
| Immunogen | Synthetic peptide generated against a sequence unique to PAC3 protein. All peptides were amidated before conjugation. |
Additional Info
| Tissue Specificity | Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level). Expressed in brain, heart, kidney, liver, lung, pancreas islets, placenta, and skeletal muscle. Detected in testis. |
| Post Translational Modifications | Sumoylated. Sumoylation is required for targeting ot olfactory cilia. N-glycosylated. Rapidly phosphorylated after stimulation by odorants or forskolin. Phosphorylation by CaMK2 at Ser-1076 down-regulates enzyme activity. |
| Function | Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis: specifically activated by G alpha protein GNAL/G(olf) in olfactory epithelium. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet. |
| Protein Name | Adenylate Cyclase Type 3Atp Pyrophosphate-Lyase 3Adenylate Cyclase Type IiiAc-IiiAdenylate Cyclase - Olfactive TypeAdenylyl Cyclase 3Ac3 |
| Database Links | Reactome: R-HSA-163359Reactome: R-HSA-163615Reactome: R-HSA-164378Reactome: R-HSA-170660Reactome: R-HSA-170670Reactome: R-HSA-381753Reactome: R-HSA-418555Reactome: R-HSA-418594Reactome: R-HSA-418597Reactome: R-HSA-432040Reactome: R-HSA-5610787Reactome: R-HSA-9634597Reactome: R-HSA-9660821Reactome: R-HSA-9664323 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmCell ProjectionCiliumGolgi ApparatusAlso Detected In The CytoplasmClose To Lipid Droplets |
| Alternative Antibody Names | Anti-Adenylate Cyclase Type 3 antibodyAnti-Atp Pyrophosphate-Lyase 3 antibodyAnti-Adenylate Cyclase Type Iii antibodyAnti-Ac-Iii antibodyAnti-Adenylate Cyclase - Olfactive Type antibodyAnti-Adenylyl Cyclase 3 antibodyAnti-Ac3 antibodyAnti-ADCY3 antibodyAnti-KIAA0511 antibody |
Information sourced from Uniprot.org