Anti-ADCY3 antibody (950-1030 aa) (STJ191725)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 950-1030
General Information
| Short Description | Rabbit polyclonal anti-Adenylate cyclase type 3 (950-1030 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ADCY3 |
| Gene ID | 109 |
| Uniprot ID | ADCY3_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 950-1030 |
| Immunogen Region | 950-1030 aa |
| Specificity | ADCY3 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Sumoylated. Sumoylation is required for targeting ot olfactory cilia. N-glycosylated. Rapidly phosphorylated after stimulation by odorants or forskolin. Phosphorylation by CaMK2 at Ser-1076 down-regulates enzyme activity. |
| Function | Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis: specifically activated by G alpha protein GNAL/G(olf) in olfactory epithelium. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet. |
| Protein Name | Adenylate Cyclase Type 3Atp Pyrophosphate-Lyase 3Adenylate Cyclase Type IiiAc-IiiAdenylate Cyclase - Olfactive TypeAdenylyl Cyclase 3Ac3 |
| Database Links | Reactome: R-HSA-163359Reactome: R-HSA-163615Reactome: R-HSA-164378Reactome: R-HSA-170660Reactome: R-HSA-170670Reactome: R-HSA-381753Reactome: R-HSA-418555Reactome: R-HSA-418594Reactome: R-HSA-418597Reactome: R-HSA-432040Reactome: R-HSA-5610787Reactome: R-HSA-9634597Reactome: R-HSA-9660821Reactome: R-HSA-9664323Reactome: R-HSA-9856530 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmCell ProjectionCiliumGolgi ApparatusAlso Detected In The CytoplasmClose To Lipid Droplets |
| Alternative Antibody Names | Anti-Adenylate Cyclase Type 3 antibodyAnti-Atp Pyrophosphate-Lyase 3 antibodyAnti-Adenylate Cyclase Type Iii antibodyAnti-Ac-Iii antibodyAnti-Adenylate Cyclase - Olfactive Type antibodyAnti-Adenylyl Cyclase 3 antibodyAnti-Ac3 antibodyAnti-ADCY3 antibodyAnti-KIAA0511 antibody |
Information sourced from Uniprot.org