| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ADCY10 |
| Gene ID: | 55811 |
| Uniprot ID: | ADCYA_HUMAN |
| Immunogen Region: | 1-290 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human ADCY10 (NP_060887.2). |
| Immunogen Sequence: | MNTPKEEFQDWPIVRIAAHL PDLIVYGHFSPERPFMDYFD GVLMFVDISGFTAMTEKFSS AMYMDRGAEQLVEILNYHIS AIVEKVLIFGGDILKFAGDA LLALWRVERKQLKNIITVVI KCSLEIHGLFETQEWEEGLD IRVKIGLAAGHISMLVFGDE THSHFLVIGQAVDDVRLAQN MAQMNDVILSPNCWQLCDRS MIEIESVPDQRAVKVNFLKP PPNFNFDEFFTKCTTFMHY |
| Tissue Specificity | Detected in airway epithelial cells and testis (at protein level). Weakly expressed in multiple tissues. Expressed in brain, heart, kidney, liver, lung, pancreas, peripheral blood leukocytes, placenta, skeletal muscle, stomach, thymus, airway epithelial cells, duodenum, jejunum and ileum. Very low level of expression in bone. |
| Post Translational Modifications | Cleavage may occur to generate the active 48 kDa form. |
| Function | Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. Involved in ciliary beat regulation. |
| Protein Name | Adenylate Cyclase Type 10 Ah-Related Protein Adenylate Cyclase Homolog Germ Cell Soluble Adenylyl Cyclase Hsac Sac Testicular Soluble Adenylyl Cyclase |
| Database Links | Reactome: R-HSA-5610787 |
| Cellular Localisation | Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Cytoplasm Cytoskeleton Perinuclear Region Nucleus Cell Projection Cilium Mitochondrion Distributed To Subcellular Compartments Containing Camp Targets Found As A Plasma Membrane-Associated Protein Protein Concentrated In The Perinuclear Region And Protein Colocalized With Actin Or Tubulin |
| Alternative Antibody Names | Anti-Adenylate Cyclase Type 10 antibody Anti-Ah-Related Protein antibody Anti-Adenylate Cyclase Homolog antibody Anti-Germ Cell Soluble Adenylyl Cyclase antibody Anti-Hsac antibody Anti-Sac antibody Anti-Testicular Soluble Adenylyl Cyclase antibody Anti-ADCY10 antibody Anti-SAC antibody |
Information sourced from Uniprot.org