| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Adenylate cyclase type 1/calmodulin-activated adenylyl cyclase (231-280 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:40000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ADCY1 |
| Gene ID: | 107 |
| Uniprot ID: | ADCY1_HUMAN |
| Immunogen Region: | 231-280 aa |
| Specificity: | A Cyclase I Polyclonal Antibody detects endogenous levels of A Cyclase I protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human ADCY1 at the amino acid range 231-280 |
| Post Translational Modifications | N-glycosylated. |
| Function | Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels. May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina. |
| Protein Name | Adenylate Cyclase Type 1 Atp Pyrophosphate-Lyase 1 Adenylate Cyclase Type I Adenylyl Cyclase 1 Ca(2+/Calmodulin-Activated Adenylyl Cyclase |
| Database Links | Reactome: R-HSA-163359 Reactome: R-HSA-163615 Reactome: R-HSA-164378 Reactome: R-HSA-170660 Reactome: R-HSA-170670 Reactome: R-HSA-418555 Reactome: R-HSA-418594 Reactome: R-HSA-418597 Reactome: R-HSA-432040 Reactome: R-HSA-442720 Reactome: R-HSA-5610787 Reactome: R-HSA-9634597 Reactome: R-HSA-9660821 Reactome: R-HSA-9664323 |
| Cellular Localisation | Membrane Multi-Pass Membrane Protein Cell Membrane Cytoplasm Membrane Raft Expressed In The Cytoplasm Of Supporting Cells And Hair Cells Of The Cochlea Vestibule As Well As To The Cochlear Hair Cell Nuclei And Stereocilia |
| Alternative Antibody Names | Anti-Adenylate Cyclase Type 1 antibody Anti-Atp Pyrophosphate-Lyase 1 antibody Anti-Adenylate Cyclase Type I antibody Anti-Adenylyl Cyclase 1 antibody Anti-Ca(2+/Calmodulin-Activated Adenylyl Cyclase antibody Anti-ADCY1 antibody |
Information sourced from Uniprot.org