| Host: |
Rabbit |
| Applications: |
WB/IHC/IF/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Double-stranded RNA-specific editase 1 (481-530 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ADARB1 |
| Gene ID: |
104 |
| Uniprot ID: |
RED1_HUMAN |
| Immunogen Region: |
481-530 aa |
| Specificity: |
ADAR2 Polyclonal Antibody detects endogenous levels of ADAR2 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human ADARB1 at the amino acid range 481-530 |
| Function | Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins.pre-mRNA splicing by altering splice site recognition sequences.RNA stability by changing sequences involved in nuclease recognition.genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication.and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis. Isoform 1: Has a lower catalytic activity than isoform 2. Isoform 2: Has a higher catalytic activity than isoform 1. |
| Protein Name | Double-Stranded Rna-Specific Editase 1Rna-Editing Deaminase 1Rna-Editing Enzyme 1Dsrna Adenosine Deaminase |
| Database Links | Reactome: R-HSA-75102Reactome: R-HSA-77042 |
| Cellular Localisation | NucleusNucleolusShuttles Between Nucleoli And The NucleoplasmIsoform 1: NucleusIsoform 2: Nucleus |
| Alternative Antibody Names | Anti-Double-Stranded Rna-Specific Editase 1 antibodyAnti-Rna-Editing Deaminase 1 antibodyAnti-Rna-Editing Enzyme 1 antibodyAnti-Dsrna Adenosine Deaminase antibodyAnti-ADARB1 antibodyAnti-ADAR2 antibodyAnti-DRADA2 antibodyAnti-RED1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
