| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
ADAMTS9 |
| Gene ID: |
56999 |
| Uniprot ID: |
ATS9_HUMAN |
| Immunogen Region: |
1520-1750 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1520-1750 of human ADAMTS9 (NP_891550.1). |
| Immunogen Sequence: |
RHVGCQIGTHKIARETECNP YTRPESERDCQGPRCPLYTW RAEEWQECTKTCGEGSRYRK VVCVDDNKNEVHGARCDVSK RPVDRESCSLQPCEYVWITG EWSECSVTCGKGYKQRLVSC SEIYTGKENYEYSYQTTINC PGTQPPSVHPCYLRDCPVSA TWRVGNWGSCSVSCGVGVMQ RSVQCLTNEDQPSHLCHTDL KPEERKTCRNVYNCELPQNC KEVKRLKGASE |
| Tissue Specificity | Highly expressed in all fetal tissues. Expressed in a number of adult tissues with highest expression in heart, placenta and skeletal muscle. |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. N-glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion. |
| Function | Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos. |
| Protein Name | A Disintegrin And Metalloproteinase With Thrombospondin Motifs 9Adam-Ts 9Adam-Ts9Adamts-9 |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-5083635Reactome: R-HSA-5173214 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixEndoplasmic Reticulum |
| Alternative Antibody Names | Anti-A Disintegrin And Metalloproteinase With Thrombospondin Motifs 9 antibodyAnti-Adam-Ts 9 antibodyAnti-Adam-Ts9 antibodyAnti-Adamts-9 antibodyAnti-ADAMTS9 antibodyAnti-KIAA1312 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
