| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-ADAMTS13 (50-150) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S6MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ADAMTS13 |
| Gene ID: |
11093 |
| Uniprot ID: |
ATS13_HUMAN |
| Immunogen Region: |
50-150 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human ADAMTS13 (Q76LX8). |
| Immunogen Sequence: |
LSPGAPLKGRPPSPGFQRQR QRQRRAAGGILHLELLVAVG PDVFQAHQEDTERYVLTNLN IGAELLRDPSLGAQFRVHLV KMVILTEPEGAPNITANLTS S |
| Tissue Specificity | Plasma. Expressed primarily in liver. |
| Post Translational Modifications | Glycosylated. O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS13. May also be C-glycosylated on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and also N-glycosylated. These other glycosylations can also facilitate secretion. The precursor is processed by a furin endopeptidase which cleaves off the pro-domain. |
| Function | Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation. |
| Protein Name | A Disintegrin And Metalloproteinase With Thrombospondin Motifs 13Adam-Ts 13Adam-Ts13Adamts-13Von Willebrand Factor-Cleaving ProteaseVwf-CpVwf-Cleaving Protease |
| Database Links | Reactome: R-HSA-5083635Reactome: R-HSA-5173214 |
| Cellular Localisation | SecretedSecretion Enhanced By O-Fucosylation Of Tsp Type-1 Repeats |
| Alternative Antibody Names | Anti-A Disintegrin And Metalloproteinase With Thrombospondin Motifs 13 antibodyAnti-Adam-Ts 13 antibodyAnti-Adam-Ts13 antibodyAnti-Adamts-13 antibodyAnti-Von Willebrand Factor-Cleaving Protease antibodyAnti-Vwf-Cp antibodyAnti-Vwf-Cleaving Protease antibodyAnti-ADAMTS13 antibodyAnti-C9orf8 antibodyAnti-UNQ6102 antibodyAnti-PRO20085 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
