| Tissue Specificity | Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy. |
| Function | Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. |
| Protein Name | Activin Receptor Type-1cActivin Receptor Type IcActr-IcActivin Receptor-Like Kinase 7Alk-7 |
| Database Links | Reactome: R-HSA-1181150Reactome: R-HSA-1433617Reactome: R-HSA-1502540 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Activin Receptor Type-1c antibodyAnti-Activin Receptor Type Ic antibodyAnti-Actr-Ic antibodyAnti-Activin Receptor-Like Kinase 7 antibodyAnti-Alk-7 antibodyAnti-ACVR1C antibodyAnti-ALK7 antibody |
Information sourced from Uniprot.org
