Anti-ACVR1C antibody (201-250 aa) (STJ91472)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human ACTR-1C at the amino acid range 201-250
General Information
| Short Description | Rabbit polyclonal anti-Activin receptor type-1C (201-250 aa) for use in IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ACVR1C |
| Gene ID | 130399 |
| Uniprot ID | ACV1C_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human ACTR-1C at the amino acid range 201-250 |
| Immunogen Region | 201-250 aa |
| Specificity | ACTR-IC Polyclonal Antibody detects endogenous levels of ACTR-IC protein. |
Additional Info
| Function | Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consists of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B, activin E and NODAL. Upon NODAL binding, activation results in increased apoptosis and reduced proliferation through suppression of AKT signaling and the activation of Smad2-dependent signaling pathway in pancreatic beta-cells, trophoblasts, epithelial or neuronal cells. Acts as a positive regulator for macrophage activation partially through down-regulation of PPARG expression. |
| Protein Name | Activin Receptor Type-1cActivin Receptor Type IcActr-IcActivin Receptor-Like Kinase 7Alk-7 |
| Database Links | Reactome: R-HSA-1181150Reactome: R-HSA-1433617Reactome: R-HSA-1502540 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Activin Receptor Type-1c antibodyAnti-Activin Receptor Type Ic antibodyAnti-Actr-Ic antibodyAnti-Activin Receptor-Like Kinase 7 antibodyAnti-Alk-7 antibodyAnti-ACVR1C antibodyAnti-ALK7 antibody |
Information sourced from Uniprot.org