| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ACTR3B |
| Gene ID: | 57180 |
| Uniprot ID: | ARP3B_HUMAN |
| Immunogen Region: | 189-418 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 189-418 of human ACTR3B (NP_065178.1). |
| Immunogen Sequence: | CIKHIPIAGRDITYFIQQLL REREVGIPPEQSLETAKAIK EKYCYICPDIVKEFAKYDVD PRKWIKQYTGINAINQKKFV IDVGYERFLGPEIFFHPEFA NPDFMESISDVVDEVIQNCP IDVRRPLYKNVVLSGGSTMF RDFGRRLQRDLKRVVDARLR LSEELSGGRIKPKPVEVQVV THHMQRYAVWFGGSMLASTP EFFQVCHTKKDYEEYGPSIC RHNPVFGVMS |
| Tissue Specificity | Detected in fetal brain. Detected throughout the adult brain, in neurons from gray matter, but not in white matter. Detected in liver, skeletal muscle and pancreas. Detected in lung adenocarcinoma cells with low metastatic potential, but not in lung adenocarcinoma cells with high metastatic potential. |
| Function | Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors. |
| Protein Name | Actin-Related Protein 3b Arp3-Beta Actin-Like Protein 3b Actin-Related Protein Arp4 |
| Cellular Localisation | Cytoplasm Cytoskeleton Cell Projection |
| Alternative Antibody Names | Anti-Actin-Related Protein 3b antibody Anti-Arp3-Beta antibody Anti-Actin-Like Protein 3b antibody Anti-Actin-Related Protein Arp4 antibody Anti-ACTR3B antibody Anti-ARP11 antibody Anti-ARP4 antibody |
Information sourced from Uniprot.org