Name: Anti-ACTH antibody [2F6] (STJ16100288)
SKU: STJ16100288
Availability: InStock

Anti-ACTH antibody [2F6] (STJ16100288)

SKU:

STJ16100288

$425.73 - $1,862.31

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Host:	Mouse
Applications:	ELISA/FC/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description :	Mouse monoclonal anti-ACTH for use in ELISA, FC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.

Clonality :	Monoclonal
Clone ID :	2F6
Conjugation:	Unconjugated
Isotype:	IgG1k
Formulation:	PBS with 0.02% Sodium Azide.
Purification:	Affinity purified from tissue culture.
Concentration:	Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL.
Dilution Range:	ELISA (solid phase: 0, 1-100 µg/ml; tracer: 0, 001-100 µg/ml for 30 min at RT). Flow cytometry (0, 5-1, 0 µg/million cells in 0, 1 ml). Immunofluorescence (0, 5-1, 0 µg/ml. Immunohistology (formalin-fixed: 2-4 µg/ml for 30 min at RT; staining of form
Storage Instruction:	Store for up to 1 year at 2-8°C upon receipt.

Gene Symbol:	MC2R
Gene ID:	4158
Uniprot ID:	ACTHR_HUMAN
Immunogen:	A BALB/c mouse was immunized with ACTH synthetic peptide (aa 1-24) conjugated to KLH.Fusion partner: SP2/0.

Tissue Specificity	Melanocytes and corticoadrenal tissue.
Post Translational Modifications	Ubiquitinated by MGRN1 that may be involved in post-endocytic trafficking and/or degradation of internalized receptor.
Function	Hormone receptor primarily expressed in adrenal cortex that plays a key role in regulating adrenocortical function. Upon corticotropin (ACTH) binding, facilitates the release of adrenal glucocorticoids, including cortisol and corticosterone. In addition, MC2R is required for fetal and neonatal adrenal gland development. Mechanistically, activates adenylate cyclase (cAMP), the MAPK cascade as well as the cAMP-dependent protein kinase A pathway leading to steroidogenic factor 1/NR5A1-mediated transcriptional activation.
Protein Name	Adrenocorticotropic Hormone Receptor Acth Receptor Acth-R Adrenocorticotropin Receptor Melanocortin Receptor 2 Mc2-R
Database Links	Reactome: R-HSA-375276 Reactome: R-HSA-418555 Reactome: R-HSA-5579031
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein
Alternative Antibody Names	Anti-Adrenocorticotropic Hormone Receptor antibody Anti-Acth Receptor antibody Anti-Acth-R antibody Anti-Adrenocorticotropin Receptor antibody Anti-Melanocortin Receptor 2 antibody Anti-Mc2-R antibody Anti-MC2R antibody Anti-ACTHR antibody

Information sourced from Uniprot.org

Model	Name	Host	Clonality	Reactivity	Application
STJ16101316	Anti-ACTH antibody (STJ16101316)	Rabbit	Polyclonal	Human	IHC-P
STJ99031	Anti-GTF2B antibody [2F6-A3] (STJ99031)	Mouse	Monoclonal	Human/Mouse/Monkey	WB
STJA0005129	Anti-ACTH antibody [SM5129] (STJA0005129)	Mouse	Monoclonal	Human	IHC/IF
STJ400340	Anti-ACTH antibody [R12801] (STJ400340)		Monoclonal	Human	ELISA

Anti-ACTH antibody [2F6] (STJ16100288)

General Information