| Short Description : | Rabbit polyclonal ACSS1 (340-689) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ACSS1 |
| Gene ID: | 84532 |
| Uniprot ID: | ACS2L_HUMAN |
| Immunogen Region: | 340-689 |
| Immunogen Sequence: | ITGHSYVVYGPLCNGATSVL FESTPVYPNAGRYWETVERL KINQFYGAPTAVRLLLKYGD AWVKKYDRSSLRTLGSVGEP INCEAWEWLHRVVGDSRCTL VDTWWQTETGGICIAPRPSE EGAEILPAMAMRPFFGIVPV LMDEKGSVVEGSNVSGALCI SQAWPGMARTIYGDHQRFVD AYFKAYPGYYFTGDGAYRTE GGYYQITGRMDDVINISGHR LGTAEIEDAIADHPAVPES |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 340-689 of human ACSS1 (NP_115890.2). |
| Post Translational Modifications | Reversibly acetylated on Lys-642. The acetyl-CoA synthase activity is inhibited by acetylation and activated by deacetylation mediated by the deacetylase SIRT3. |
| Function | Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity. Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions. Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient. |
| Protein Name | Acetyl-Coenzyme A Synthetase 2-Like - MitochondrialAcetate--Coa Ligase 2Acetyl-Coa Synthetase 2Acecs2Acyl-Coa Synthetase Short-Chain Family Member 1Propionate--Coa Ligase |
| Database Links | Reactome: R-HSA-71384 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Acetyl-Coenzyme A Synthetase 2-Like - Mitochondrial antibodyAnti-Acetate--Coa Ligase 2 antibodyAnti-Acetyl-Coa Synthetase 2 antibodyAnti-Acecs2 antibodyAnti-Acyl-Coa Synthetase Short-Chain Family Member 1 antibodyAnti-Propionate--Coa Ligase antibodyAnti-ACSS1 antibodyAnti-ACAS2L antibodyAnti-KIAA1846 antibody |
Information sourced from Uniprot.org
