| Post Translational Modifications | Reversibly acetylated on Lys-642. The acetyl-CoA synthase activity is inhibited by acetylation and activated by deacetylation mediated by the deacetylase SIRT3. |
| Function | Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity. Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions. Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient. |
| Protein Name | Acetyl-Coenzyme A Synthetase 2-Like - MitochondrialAcetate--Coa Ligase 2Acetyl-Coa Synthetase 2Acecs2Acyl-Coa Synthetase Short-Chain Family Member 1Propionate--Coa Ligase |
| Database Links | Reactome: R-HSA-71384 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Acetyl-Coenzyme A Synthetase 2-Like - Mitochondrial antibodyAnti-Acetate--Coa Ligase 2 antibodyAnti-Acetyl-Coa Synthetase 2 antibodyAnti-Acecs2 antibodyAnti-Acyl-Coa Synthetase Short-Chain Family Member 1 antibodyAnti-Propionate--Coa Ligase antibodyAnti-ACSS1 antibodyAnti-ACAS2L antibodyAnti-KIAA1846 antibody |
Information sourced from Uniprot.org
