| Function | Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage. Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids. It was suggested that it may also stimulate fatty acid oxidation. At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells. |
| Protein Name | Long-Chain-Fatty-Acid--Coa Ligase 5Arachidonate--Coa LigaseLong-Chain Acyl-Coa Synthetase 5Lacs 5 |
| Database Links | Reactome: R-HSA-75876 |
| Cellular Localisation | MitochondrionEndoplasmic ReticulumMitochondrion Outer MembraneSingle-Pass Type Iii Membrane ProteinEndoplasmic Reticulum MembraneCell Membrane |
| Alternative Antibody Names | Anti-Long-Chain-Fatty-Acid--Coa Ligase 5 antibodyAnti-Arachidonate--Coa Ligase antibodyAnti-Long-Chain Acyl-Coa Synthetase 5 antibodyAnti-Lacs 5 antibodyAnti-ACSL5 antibodyAnti-ACS5 antibodyAnti-FACL5 antibodyAnti-UNQ633 antibodyAnti-PRO1250 antibody |
Information sourced from Uniprot.org
