Anti-ACSL5 antibody (500-739) (STJ22493)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ACSL5 (500-739) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ACSL5 |
| Gene ID | 51703 |
| Uniprot ID | ACSL5_HUMAN |
| Immunogen Region | 500-739 |
| Immunogen Sequence | GQTECTGGCTFTLPGDWTSG HVGVPLACNYVKLEDVADMN YFTVNNEGEVCIKGTNVFKG YLKDPEKTQEALDSDGWLHT GDIGRWLPNGTLKIIDRKKN IFKLAQGEYIAPEKIENIYN RSQPVLQIFVHGESLRSSLV GVVVPDTDVLPSFAAKLGVK GSFEELCQNQVVREAILEDL QKIGKESGLKTFEQVKAIFL HPEPFSIENGLLTPTLKAKR GELSKYFRTQIDSLYEHIQ |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 500-739 of human ACSL5 (NP_057318.2). |
Additional Info
| Function | Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage. Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids. It was suggested that it may also stimulate fatty acid oxidation. At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells. |
| Protein Name | Long-Chain-Fatty-Acid--Coa Ligase 5Arachidonate--Coa LigaseLong-Chain Acyl-Coa Synthetase 5Lacs 5 |
| Database Links | Reactome: R-HSA-75876 |
| Cellular Localisation | MitochondrionEndoplasmic ReticulumMitochondrion Outer MembraneSingle-Pass Type Iii Membrane ProteinEndoplasmic Reticulum MembraneCell Membrane |
| Alternative Antibody Names | Anti-Long-Chain-Fatty-Acid--Coa Ligase 5 antibodyAnti-Arachidonate--Coa Ligase antibodyAnti-Long-Chain Acyl-Coa Synthetase 5 antibodyAnti-Lacs 5 antibodyAnti-ACSL5 antibodyAnti-ACS5 antibodyAnti-FACL5 antibodyAnti-UNQ633 antibodyAnti-PRO1250 antibody |
Information sourced from Uniprot.org