| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/IP/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S9MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:58000-1:232000IHC-P:1:200-1:2000IF/ICC:1:200-1:800IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ACSL4 |
| Gene ID: | 2182 |
| Uniprot ID: | ACSL4_HUMAN |
| Immunogen Region: | 42-321 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 42-321 of human ACSL4 (NP_075266.1). |
| Immunogen Sequence: | MAKRIKAKPTSDKPGSPYRS VTHFDSLAVIDIPGADTLDK LFDHAVSKFGKKDSLGTREI LSEENEMQPNGKVFKKLILG NYKWMNYLEVNRRVNNFGSG LTALGLKPKNTIAIFCETRA EWMIAAQTCFKYNFPLVTLY ATLGKEAVVHGLNESEASYL ITSVELLESKLKTALLDISC VKHIIYVDNKAINKAEYPEG FEIHSMQSVEELGSNPENLG IPPSRPTPSDMAIVMYTSG |
| Function | Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs. Modulates prostaglandin E2 secretion. |
| Protein Name | Long-Chain-Fatty-Acid--Coa Ligase 4Arachidonate--Coa LigaseLong-Chain Acyl-Coa Synthetase 4Lacs 4 |
| Database Links | Reactome: R-HSA-434313Reactome: R-HSA-75876 |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Type Iii Membrane ProteinPeroxisome MembraneMicrosome MembraneEndoplasmic Reticulum MembraneCell Membrane |
| Alternative Antibody Names | Anti-Long-Chain-Fatty-Acid--Coa Ligase 4 antibodyAnti-Arachidonate--Coa Ligase antibodyAnti-Long-Chain Acyl-Coa Synthetase 4 antibodyAnti-Lacs 4 antibodyAnti-ACSL4 antibodyAnti-ACS4 antibodyAnti-FACL4 antibodyAnti-LACS4 antibody |
Information sourced from Uniprot.org