Anti-ACMSD antibody (1-336) (STJ118398)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ACMSD (1-336) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ACMSD |
| Gene ID | 130013 |
| Uniprot ID | ACMSD_HUMAN |
| Immunogen Region | 1-336 |
| Immunogen Sequence | MKIDIHSHILPKEWPDLKKR FGYGGWVQLQHHSKGEAKLL KDGKVFRVVRENCWDPEVRI REMDQKGVTVQALSTVPVMF SYWAKPEDTLNLCQLLNNDL ASTVVSYPRRFVGLGTLPMQ APELAVKEMERCVKELGFPG VQIGTHVNEWDLNAQELFPV YAAAERLKCSLFVHPWDMQM DGRMAKYWLPWLVGMPAETT IAICSMIMGGVFEKFPKLKV CFAHGGGAFPFTVGRISHG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-336 of human ACMSD (NP_612199.2). |
Additional Info
| Function | Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. |
| Protein Name | 2-Amino-3-Carboxymuconate-6-Semialdehyde DecarboxylasePicolinate Carboxylase |
| Database Links | Reactome: R-HSA-71240 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-2-Amino-3-Carboxymuconate-6-Semialdehyde Decarboxylase antibodyAnti-Picolinate Carboxylase antibodyAnti-ACMSD antibody |
Information sourced from Uniprot.org