| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ACMSD (1-336) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ACMSD |
| Gene ID: |
130013 |
| Uniprot ID: |
ACMSD_HUMAN |
| Immunogen Region: |
1-336 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-336 of human ACMSD (NP_612199.2). |
| Immunogen Sequence: |
MKIDIHSHILPKEWPDLKKR FGYGGWVQLQHHSKGEAKLL KDGKVFRVVRENCWDPEVRI REMDQKGVTVQALSTVPVMF SYWAKPEDTLNLCQLLNNDL ASTVVSYPRRFVGLGTLPMQ APELAVKEMERCVKELGFPG VQIGTHVNEWDLNAQELFPV YAAAERLKCSLFVHPWDMQM DGRMAKYWLPWLVGMPAETT IAICSMIMGGVFEKFPKLKV CFAHGGGAFPFTVGRISHG |
| Function | Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. |
| Protein Name | 2-Amino-3-Carboxymuconate-6-Semialdehyde DecarboxylasePicolinate Carboxylase |
| Database Links | Reactome: R-HSA-71240 |
| Alternative Antibody Names | Anti-2-Amino-3-Carboxymuconate-6-Semialdehyde Decarboxylase antibodyAnti-Picolinate Carboxylase antibodyAnti-ACMSD antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
