| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ACHE |
| Gene ID: | 43 |
| Uniprot ID: | ACES_HUMAN |
| Immunogen Region: | 398-617 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 398-617 of human ACHE (NP_056646.1). |
| Immunogen Sequence: | VPQVSDLAAEAVVLHYTDWL HPEDPARLREALSDVVGDHN VVCPVAQLAGRLAAQGARVY AYVFEHRASTLSWPLWMGVP HGYEIEFIFGIPLDPSRNYT AEEKIFAQRLMRYWANFART GDPNEPRDPKAPQWPPYTAG AQQYVSLDLRPLEVRRGLRA QACAFWNRFLPKLLSATASE APSTCPGFTHGEAAPRPGLP LPLLLLHQLLLLFLSHLRRL |
| Tissue Specificity | Isoform H is highly expressed in erythrocytes. |
| Function | Hydrolyzes rapidly the acetylcholine neurotransmitter released into the synaptic cleft allowing to terminate the signal transduction at the neuromuscular junction. Role in neuronal apoptosis. |
| Protein Name | AcetylcholinesteraseAche |
| Database Links | Reactome: R-HSA-112311Reactome: R-HSA-1483191Reactome: R-HSA-422085 |
| Cellular Localisation | SynapseSecretedCell MembranePeripheral Membrane ProteinIsoform T: NucleusOnly Observed In Apoptotic NucleiIsoform H: Cell MembraneLipid-AnchorGpi-AnchorExtracellular Side |
| Alternative Antibody Names | Anti-Acetylcholinesterase antibodyAnti-Ache antibodyAnti-ACHE antibody |
Information sourced from Uniprot.org