| Post Translational Modifications | Phosphorylated on serine residues by PKA. Phosphorylation by PKA enhances its DNA-binding activity and stimulates transcription repression. Acetylation of Lys-136 contributes to its nuclear localization and enhances its interaction with KPNB1. Deacetylated by HDAC3. Poly-ADP-ribosylated by PARP1. ADP-ribosylation reduces its DNA-binding activity. |
| Function | Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-ATAACAAAT-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. |
| Protein Name | Sex-Determining Region Y ProteinTestis-Determining Factor |
| Database Links | Reactome: R-HSA-3769402Reactome: R-HSA-9690406 |
| Cellular Localisation | Nucleus SpeckleCytoplasmNucleusAcetylation Contributes To Its Nuclear Localization And Deacetylation By Hdac3 Induces A Cytoplasmic DelocalizationColocalizes With Sox6 In SpecklesColocalizes With Caml In The NucleusColocalizes In The Nucleus With Znf208 Isoform Krab-O And Tyrosine Hydroxylase (Th)Nuclear Import Is Facilitated By Xpo4A Protein That Usually Acts As A Nuclear Export Signal Receptor |
| Alternative Antibody Names | Anti-Sex-Determining Region Y Protein antibodyAnti-Testis-Determining Factor antibodyAnti-SRY antibodyAnti-TDF antibody |
Information sourced from Uniprot.org
