| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Acetyl-Transcription factor E2F1-K125 is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 ELISA 1:20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | E2F1 |
| Gene ID: | 1869 |
| Uniprot ID: | E2F1_HUMAN |
| Specificity: | This antibody detects endogenous levels of E2F-1 at Human:K125;Mouse:K120;Rat:K123, It doesn t reacte with total protein. |
| Immunogen: | Synthesized Acetyl peptide derived from the human E2F-1. at the amino acid range K125 |
| Function | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTCCGCGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters. Directly activates transcription of PEG10. Positively regulates transcription of RRP1B. |
| Protein Name | Transcription Factor E2f1 E2f-1 Pbr3 Retinoblastoma-Associated Protein 1 Rbap-1 Retinoblastoma-Binding Protein 3 Rbbp-3 Prb-Binding Protein E2f-1 |
| Database Links | Reactome: R-HSA-111448 Reactome: R-HSA-113501 Reactome: R-HSA-1362277 Reactome: R-HSA-1362300 Reactome: R-HSA-139915 Reactome: R-HSA-1912408 Reactome: R-HSA-2559580 Reactome: R-HSA-2559585 Reactome: R-HSA-6804116 Reactome: R-HSA-68911 Reactome: R-HSA-69202 Reactome: R-HSA-69205 Reactome: R-HSA-69231 Reactome: R-HSA-69656 Reactome: R-HSA-8953750 Reactome: R-HSA-9616222 Reactome: R-HSA-9661069 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor E2f1 antibody Anti-E2f-1 antibody Anti-Pbr3 antibody Anti-Retinoblastoma-Associated Protein 1 antibody Anti-Rbap-1 antibody Anti-Retinoblastoma-Binding Protein 3 antibody Anti-Rbbp-3 antibody Anti-Prb-Binding Protein E2f-1 antibody Anti-E2F1 antibody Anti-RBBP3 antibody |
Information sourced from Uniprot.org