Anti-ACADM, Biotinylated antibody (C-Term) {Biotin} (STJ73260)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationBiotin
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-ACADM, Biotinylated (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 45kDa band observed in Human Heart lysates (calculated MW of 46.6kDa according to NP_000007.1). See non-biotinylated parental product's datasheet for further QC data. Recommende |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | ACADM |
| Gene ID | 34 |
| Uniprot ID | ACADM_HUMAN |
| Accession Number | NP_000007.1; NP_001120800.1; NP_001272971.1; NP_001272972.1; NP_001272973.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | RLIVAREHIDKYKN. |
| Specificity | This antibody is expected to recognise both reported isoforms (NP_000007.1; NP_001120800.1). |
Additional Info
| Function | Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Electron transfer flavoprotein (ETF) is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 6 to 12 carbons long primary chains. |
| Protein Name | Medium-Chain Specific Acyl-Coa Dehydrogenase - MitochondrialMcadMedium Chain Acyl-Coa DehydrogenaseMcadh |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-77288Reactome: R-HSA-77346Reactome: R-HSA-77348 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Medium-Chain Specific Acyl-Coa Dehydrogenase - Mitochondrial antibodyAnti-Mcad antibodyAnti-Medium Chain Acyl-Coa Dehydrogenase antibodyAnti-Mcadh antibodyAnti-ACADM antibody |
Information sourced from Uniprot.org