Anti-ACAA2 antibody (298-397) [S4MR] (STJ11102704)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal ACAA2 (298-397) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S4MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ACAA2 |
| Gene ID | 10449 |
| Uniprot ID | THIM_HUMAN |
| Immunogen Region | 298-397 |
| Immunogen Sequence | PAISGALKKAGLSLKDMDLV EVNEAFAPQYLAVERSLDLD ISKTNVNGGAIALGHPLGGS GSRITAHLVHELRRRGGKYA VGSACIGGGQGIAVIIQSTA |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 298-397 of human ACAA2 (P42765). |
Additional Info
| Function | In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs. Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage. |
| Protein Name | 3-Ketoacyl-Coa Thiolase - MitochondrialAcetyl-Coa AcetyltransferaseAcetyl-Coa AcyltransferaseAcyl-Coa Hydrolase - MitochondrialBeta-KetothiolaseMitochondrial 3-Oxoacyl-Coa ThiolaseT1 |
| Database Links | Reactome: R-HSA-77289 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-3-Ketoacyl-Coa Thiolase - Mitochondrial antibodyAnti-Acetyl-Coa Acetyltransferase antibodyAnti-Acetyl-Coa Acyltransferase antibodyAnti-Acyl-Coa Hydrolase - Mitochondrial antibodyAnti-Beta-Ketothiolase antibodyAnti-Mitochondrial 3-Oxoacyl-Coa Thiolase antibodyAnti-T1 antibodyAnti-ACAA2 antibody |
Information sourced from Uniprot.org