| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ACAA2 (1-250) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ACAA2 |
| Gene ID: |
10449 |
| Uniprot ID: |
THIM_HUMAN |
| Immunogen Region: |
1-250 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human ACAA2 (NP_006102.2). |
| Immunogen Sequence: |
MALLRGVFVVAAKRTPFGAY GGLLKDFTATDLSEFAAKAA LSAGKVSPETVDSVIMGNVL QSSSDAIYLARHVGLRVGIP KETPALTINRLCGSGFQSIV NGCQEICVKEAEVVLCGGTE SMSQAPYCVRNVRFGTKLGS DIKLEDSLWVSLTDQHVQLP MAMTAENLAVKHKISREECD KYALQSQQRWKAANDAGYFN DEMAPIEVKTKKGKQTMQVD EHARPQTTLEQLQKLPPVF |
| Function | In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs. Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage. |
| Protein Name | 3-Ketoacyl-Coa Thiolase - MitochondrialAcetyl-Coa AcetyltransferaseAcetyl-Coa AcyltransferaseAcyl-Coa Hydrolase - MitochondrialBeta-KetothiolaseMitochondrial 3-Oxoacyl-Coa ThiolaseT1 |
| Database Links | Reactome: R-HSA-77289 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-3-Ketoacyl-Coa Thiolase - Mitochondrial antibodyAnti-Acetyl-Coa Acetyltransferase antibodyAnti-Acetyl-Coa Acyltransferase antibodyAnti-Acyl-Coa Hydrolase - Mitochondrial antibodyAnti-Beta-Ketothiolase antibodyAnti-Mitochondrial 3-Oxoacyl-Coa Thiolase antibodyAnti-T1 antibodyAnti-ACAA2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
