| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ABHD6 (51-336) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Abhd6 |
| Gene ID: |
66082 |
| Uniprot ID: |
ABHD6_MOUSE |
| Immunogen Region: |
51-336 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 51-336 of human ABHD6 (NP_079617.2). |
| Immunogen Sequence: |
RYAHHEDYQFCYSFRGRPGH KPSILMLHGFSAHKDMWLSV VKFLPKNLHLVCVDMPGHEG TTRSSLDDLSIVGQVKRIHQ FVECLKLNKKPFHLIGTSMG GHVAGVYAAYYPSDVCSLSL VCPAGLQYSTDNPFVQRLKE LEESAAIQKIPLIPSTPEEM SEMLQLCSYVRFKVPQQILQ GLVDVRIPHNSFYRKLFLEI VNEKSRYSLHENMDKIKVPT QIIWGKQDQVLDVSGADIL |
| Tissue Specificity | Widely expressed with higher expression in small intestine, liver and brown adipose tissue. In brain, expressed postsynaptically in cortical neurons but not detected in microglia (at protein level). |
| Function | Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids. Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting. |
| Protein Name | Monoacylglycerol Lipase Abhd62-Arachidonoylglycerol HydrolaseAbhydrolase Domain-Containing Protein 6 |
| Database Links | Reactome: R-MMU-426048 |
| Cellular Localisation | Late Endosome MembraneSingle-Pass Type Ii Membrane ProteinLysosome MembraneMitochondrion Membrane |
| Alternative Antibody Names | Anti-Monoacylglycerol Lipase Abhd6 antibodyAnti-2-Arachidonoylglycerol Hydrolase antibodyAnti-Abhydrolase Domain-Containing Protein 6 antibodyAnti-Abhd6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
