Anti-ABCC5 antibody (10-60 aa) (STJ13100704)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 10-60 of human ABCC5 conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-ABCC5 (10-60 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB (recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | ABCC5 |
| Gene ID | 10057 |
| Uniprot ID | MRP5_HUMAN |
| Immunogen | A synthetic peptide from aa region 10-60 of human ABCC5 conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | 10-60 aa |
| Specificity | Specific for ABCC5. |
Additional Info
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro). Also acts as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins. Confers resistance to the antiviral agent PMEA. Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated. Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway. May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 5Multi-Specific Organic Anion Transporter CMoat-CMultidrug Resistance-Associated Protein 5SmrpPabc11 |
| Database Links | Reactome: R-HSA-2142850Reactome: R-HSA-382556Reactome: R-HSA-9748787Reactome: R-HSA-9753281 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinGolgi Apparatus LumenEndosome MembraneCytoplasmic GranuleApical Cell MembraneIn Most CellsRoutes To The Basolateral Plasma MembraneBut In The Brain Capillary Endothelial Cells That Form The Blood-Brain BarrierResides In The Apical Membrane |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family C Member 5 antibodyAnti-Multi-Specific Organic Anion Transporter C antibodyAnti-Moat-C antibodyAnti-Multidrug Resistance-Associated Protein 5 antibodyAnti-Smrp antibodyAnti-Pabc11 antibodyAnti-ABCC5 antibodyAnti-MRP5 antibody |
Information sourced from Uniprot.org