| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ABCC2 (900-950 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB (recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
ABCC2 |
| Gene ID: |
1244 |
| Uniprot ID: |
MRP2_HUMAN |
| Immunogen Region: |
900-950 aa |
| Specificity: |
Specific for ABCC2. |
| Immunogen: |
A synthetic peptide from aa region 900-950 of human ABCC2 conjugated to an immunogenic carrier protein was used as the antigen. |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates. Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification. Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Transports sulfated bile salt such as taurolithocholate sulfate. Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors. Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 2 Canalicular Multidrug Resistance ProteinCanalicular Multispecific Organic Anion Transporter 1Multidrug Resistance-Associated Protein 2 |
| Database Links | Reactome: R-HSA-189483Reactome: R-HSA-382556Reactome: R-HSA-5679001Reactome: R-HSA-9749641Reactome: R-HSA-9753281Reactome: R-HSA-9754706 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinLocalized To The Apical Membrane Of Enterocytes |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family C Member 2 antibodyAnti-Canalicular Multidrug Resistance Protein antibodyAnti-Canalicular Multispecific Organic Anion Transporter 1 antibodyAnti-Multidrug Resistance-Associated Protein 2 antibodyAnti-ABCC2 antibodyAnti-CMOAT antibodyAnti-CMOAT1 antibodyAnti-CMRP antibodyAnti-MRP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
