| Tissue Specificity | Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver. Expressed in small intestine. |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates. Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification. Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Transports sulfated bile salt such as taurolithocholate sulfate. Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors. Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 2 Canalicular Multidrug Resistance ProteinCanalicular Multispecific Organic Anion Transporter 1Multidrug Resistance-Associated Protein 2 |
| Database Links | Reactome: R-HSA-189483Reactome: R-HSA-382556Reactome: R-HSA-5679001Reactome: R-HSA-9749641Reactome: R-HSA-9753281Reactome: R-HSA-9754706 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinLocalized To The Apical Membrane Of Enterocytes |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family C Member 2 antibodyAnti-Canalicular Multidrug Resistance Protein antibodyAnti-Canalicular Multispecific Organic Anion Transporter 1 antibodyAnti-Multidrug Resistance-Associated Protein 2 antibodyAnti-ABCC2 antibodyAnti-CMOAT antibodyAnti-CMOAT1 antibodyAnti-CMRP antibodyAnti-MRP2 antibody |
Information sourced from Uniprot.org
