| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Mouse/Rat/Dog/Pig/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-ABCC1 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 150kDa band observed in lysates of cell line A549 (calculated MW of 159kDa according to NP_063954.2). Recommended concentration:0.05-0.2µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | ABCC1 |
| Gene ID: | 4363 |
| Uniprot ID: | MRP1_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_004987.2; NP_063915.2; NP_063953.2; NP_063954.2; NP_063955.2 |
| Specificity: | This antibody is expected to recognize all reported isoforms (NP_004987.2; NP_063915.2; NP_063953.2; NP_063954.2; NP_063955.2). |
| Immunogen Sequence: | HQSDLKVDENQKAYY |
| Function | Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation. Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells. Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export. Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway. |
| Protein Name | Multidrug Resistance-Associated Protein 1Atp-Binding Cassette Sub-Family C Member 1Glutathione-S-Conjugate-Translocating Atpase Abcc1Leukotriene C(4 TransporterLtc4 Transporter |
| Database Links | Reactome: R-HSA-1660661Reactome: R-HSA-189483Reactome: R-HSA-2142691Reactome: R-HSA-382556Reactome: R-HSA-9707564Reactome: R-HSA-9753281Reactome: R-HSA-9758890Reactome: R-HSA-9818032 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Multidrug Resistance-Associated Protein 1 antibodyAnti-Atp-Binding Cassette Sub-Family C Member 1 antibodyAnti-Glutathione-S-Conjugate-Translocating Atpase Abcc1 antibodyAnti-Leukotriene C(4 Transporter antibodyAnti-Ltc4 Transporter antibodyAnti-ABCC1 antibodyAnti-MRP antibodyAnti-MRP1 antibody |
Information sourced from Uniprot.org