| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ABCC1 |
| Gene ID: | 4363 |
| Uniprot ID: | MRP1_HUMAN |
| Immunogen Region: | 850-1531 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 850-960 of human MRP1/ABCC1 (NP_004987.2). |
| Immunogen Sequence: | GSYQELLARDGAFAEFLRTY ASTEQEQDAEENGVTGVSGP GKEAKQMENGMLVTDSAGKQ LQRQLSSSSSYSGDISRHHN STAELQKAEAKKEETWKLME ADKAQTGQVKL |
| Tissue Specificity | Lung, testis and peripheral blood mononuclear cells. |
| Function | Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation. Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells. Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export. Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway. |
| Protein Name | Multidrug Resistance-Associated Protein 1 Atp-Binding Cassette Sub-Family C Member 1 Glutathione-S-Conjugate-Translocating Atpase Abcc1 Leukotriene C(4 Transporter Ltc4 Transporter |
| Database Links | Reactome: R-HSA-1660661 Reactome: R-HSA-189483 Reactome: R-HSA-2142691 Reactome: R-HSA-382556 Reactome: R-HSA-9707564 Reactome: R-HSA-9753281 Reactome: R-HSA-9758890 Reactome: R-HSA-9818032 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Multidrug Resistance-Associated Protein 1 antibody Anti-Atp-Binding Cassette Sub-Family C Member 1 antibody Anti-Glutathione-S-Conjugate-Translocating Atpase Abcc1 antibody Anti-Leukotriene C(4 Transporter antibody Anti-Ltc4 Transporter antibody Anti-ABCC1 antibody Anti-MRP antibody Anti-MRP1 antibody |
Information sourced from Uniprot.org