| Short Description : | Rabbit polyclonal ABCB7 (503-753) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ABCB7 |
| Gene ID: | 22 |
| Uniprot ID: | ABCB7_HUMAN |
| Immunogen Region: | 503-753 |
| Immunogen Sequence: | AIVGGSGSGKSTIVRLLFRF YEPQKGSIYLAGQNIQDVSL ESLRRAVGVVPQDAVLFHNT IYYNLLYGNISASPEEVYAV AKLAGLHDAILRMPHGYDTQ VGERGLKLSGGEKQRVAIAR AILKDPPVILYDEATSSLDS ITEETILGAMKDVVKHRTSI FIAHRLSTVVDADEIIVLDQ GKVAERGTHHGLLANPHSIY SEMWHTQSSRVQNHDNPKWE AKKENISKEEERKKLQEEI |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 503-753 of human ABCB7 (NP_004290.2). |
| Function | Exports glutathione-coordinated iron-sulfur clusters such as 2Fe-2S-(GS)4 cluster from the mitochondria to the cytosol in an ATP-dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins and participates in iron homeostasis. Moreover, through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis. In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1. May also play a role in hematopoiesis. |
| Protein Name | Iron-Sulfur Clusters Transporter Abcb7 - MitochondrialAtp-Binding Cassette Sub-Family B Member 7 - MitochondrialAtp-Binding Cassette Transporter 7Abc Transporter 7 Protein |
| Database Links | Reactome: R-HSA-1369007Reactome: R-HSA-2564830 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Iron-Sulfur Clusters Transporter Abcb7 - Mitochondrial antibodyAnti-Atp-Binding Cassette Sub-Family B Member 7 - Mitochondrial antibodyAnti-Atp-Binding Cassette Transporter 7 antibodyAnti-Abc Transporter 7 Protein antibodyAnti-ABCB7 antibodyAnti-ABC7 antibody |
Information sourced from Uniprot.org
