| Function | ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen. May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress. May play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils. In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin. In addition may play a role in the transition metal homeostasis. |
| Protein Name | Atp-Binding Cassette Sub-Family B Member 6Abc-Type Heme Transporter Abcb6 |
| Database Links | Reactome: R-MMU-1369007 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMitochondrion Outer MembraneEndoplasmic Reticulum MembraneGolgi Apparatus MembraneEndosome MembraneLysosome MembraneLate Endosome MembraneEarly Endosome MembraneSecretedExtracellular ExosomeMitochondrionEndosomeMultivesicular Body MembraneMelanosome MembranePresent In The Membrane Of Mature Erythrocytes And In Exosomes Released From Reticulocytes During The Final Steps Of Erythroid MaturationTraffics From Endoplasmic Reticulum To Golgi During Its Glycans's MaturationTherefrom Is First Targeted To The Plasma MembraneAnd Is Rapidly Internalized Through Endocytosis To Be Distributed To The Limiting Membrane Of Multivesicular Bodies And LysosomesLocalized On The Limiting Membrane Of Early Melanosomes Of Pigment CellsTargeted To The Endolysosomal Compartment |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family B Member 6 antibodyAnti-Abc-Type Heme Transporter Abcb6 antibodyAnti-Abcb6 antibody |
Information sourced from Uniprot.org
