Host: | Goat |
Applications: | Pep-ELISA |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Goat polyclonal antibody anti-ABCA8 (C-Term) is suitable for use in ELISA research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
Concentration: | 0.5 mg/mL |
Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:4000.WB: Preliminary experiments gave an approx. 50-55kDa band in Human Brain (Cerebellum, Cerebral Cortex, Frontal Cortex) , Heart, Skeletal Muscle and Testis lysates after 0.3µg/ml antibody st |
Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Gene Symbol: | ABCA8 |
Gene ID: | 10351 |
Uniprot ID: | ABCA8_HUMAN |
Immunogen Region: | C-Term |
Accession Number: | NP_009099.1 |
Specificity: | This antibody is expected to cross-react with the highly similar Human ABCA9, since the immunizing peptide differs from ABCA9 with only one residue (F8). |
Immunogen Sequence: | KEQELGDFEEDFD |
Function | Isoform 1: Catalyzes ATP-dependent import of organic anions such as taurocholate and estrone sulfate. In vitro, also imports ochratoxin A. Also mediates cholesterol efflux independent of apolipoprotein, and plays a role in sphingomyelin production in oligodendrocytes. Isoform 3: Catalyzes ATP-dependent efflux of cholesterol and taurocholate. Interaction with ABCA1 potentiates cholesterol efflux to lipid-free APOA1, which regulates high-density lipoprotein cholesterol levels. |
Protein Name | Abc-Type Organic Anion Transporter Abca8Atp-Binding Cassette Sub-Family A Member 8 |
Database Links | Reactome: R-HSA-382556 |
Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembranePredominantly Expressed On The Sinusoidal Plasma Membrane |
Alternative Antibody Names | Anti-Abc-Type Organic Anion Transporter Abca8 antibodyAnti-Atp-Binding Cassette Sub-Family A Member 8 antibodyAnti-ABCA8 antibodyAnti-KIAA0822 antibody |
Information sourced from Uniprot.org